Exploratory Analysis of ¹⁸F-3'-deoxy-3'-fluorothymidine (¹⁸F-FLT) PET/CT-Based Radiomics for the Early Evaluation of Response to Neoadjuvant Chemotherapy in Patients With Locally Advanced Breast Cancer.

ABSTRACT:

Purpose

The objective of this study was to evaluate a set of radiomics-based advanced textural features extracted from ¹⁸F-FLT-PET/CT images to predict tumor response to neoadjuvant chemotherapy (NCT) in patients with locally advanced breast cancer (BC).

Materials and methods

Patients with operable (T2-T3, N0-N2, M0) or locally advanced (T4, N0-N2, M0) BC were enrolled. All patients underwent chemotherapy (six cycles every 3 weeks). Surgery was performed within 4 weeks of the end of NCT. The MD Anderson Residual Cancer Burden calculator was used to evaluate the pathological response. ¹⁸F-FLT-PET/CT was performed 2 weeks before the start of NCT and approximately 3 weeks after the first cycle. The evaluation of PET response was based on EORTC criteria. St

SUBMITTER: Fantini L 

PROVIDER: S-EPMC8264651 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature