Identification of genes associated with sudden cardiac death: a network- and pathway-based approach.

ABSTRACT:

Background

Sudden cardiac death (SCD) accounts for a large proportion of the total deaths across different age groups. Although numerous candidate genes related to SCD have been identified by genetic association studies and genome wide association studies (GWAS), the molecular mechanisms underlying SCD are still unclear, and the biological functions and interactions of these genes remain obscure. To clarify this issue, we performed a comprehensive and systematic analysis of SCD-related genes by a network and pathway-based approach.

Methods

By screening the publications deposited in the PubMed and Gene-Cloud Biotechnology Information (GCBI) databases, we collected the genes genetically associated with SCD, which were referred to as the SCD-related gene set (SCDgset). To analy

SUBMITTER: Wei J 

PROVIDER: S-EPMC8264674 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature