Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from other forms of cell death in morphology, biochemistry, and genetics, and has played a vital role in cancer biology. This study aimed to identify a ferroptosis-related gene signature associated with LUAD prognosis.

Methods

Dataset TCGA-LUAD which came from the TCGA portal was taken as the training cohort. GSE72094 and GSE68465 from the GEO database were treated as validation cohorts. Two hundred fifty-nine ferroptosis-related genes were retrieved from the FerrDb database. In the training cohort, Kaplan-Meier and univariate Cox analyses were conducted for preliminary screening of ferroptosis-related gen

SUBMITTER: Zhang A 

PROVIDER: S-EPMC8264775 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature