Single-Entity Electrochemistry for Digital Biosensing at Ultralow Concentrations.

ABSTRACT: Quantifying ultralow analyte concentrations is a continuing challenge in the analytical sciences in general and in electrochemistry in particular. Typical hurdles for affinity sensors at low concentrations include achieving sufficiently efficient mass transport of the analyte, dealing with slow reaction kinetics, and detecting a small transducer signal against a background signal that itself fluctuates slowly in time. Recent decades have seen the advent of methods capable of detecting single analytes ranging from the nanoscale to individual molecules, representing the ultimate mass sensitivity to these analytes. However, single-entity detection does not automatically translate into a superior concentration sensitivity. This is largely because electrochemical transducers capable of such det

SUBMITTER: Lemay SG 

PROVIDER: S-EPMC8264825 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature