Is ghrelin a biomarker of early-onset scoliosis in children with Prader-Willi syndrome?

ABSTRACT:

Background

Adolescents with idiopathic scoliosis display high ghrelin levels. As hyperghrelinemia is found in patients with PWS and early-onset scoliosis (EOS) is highly prevalent in these patients, our aims were to explore (1) whether ghrelin levels differ between those with and without EOS and correlate with scoliosis severity, and (2) whether ghrelin levels in the first year of life are associated with the later development of EOS.

Methods

We used a case control study design for the first question and a longitudinal design for the second. Patients with PWS having plasma ghrelin measurements recorded between 2013 and 2018 in our database were selected and 30 children < 10 years old with EOS and 30 age- and BMI-matched controls without EOS were included. The Cobb angle at d

SUBMITTER: Pacoricona Alfaro DL 

PROVIDER: S-EPMC8265004 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature