Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children.

ABSTRACT:

Background

Priming for cardiometabolic diseases, including non-alcoholic fatty liver disease (NAFLD), is hypothesized to begin in utero. The primary objective of this study is to determine whether there is an association between maternal nutritional status and offspring NAFLD.

Methods

Data come from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the UK. The analytic sample included 3353 participants who had maternal information on pre-pregnancy BMI, gestational weight gain, diabetes, and free sugar intake as percent of total energy and were assessed for mild-severe hepatic steatosis at 24 years by transient elastography (controlled attenuation parameter score ≥ 248 dB/m). Multiple logistic regression was used to evaluate the association between maternal fact

SUBMITTER: Sekkarie A 

PROVIDER: S-EPMC8265091 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature