Chandipura virus dysregulates the expression of hsa-miR-21-5p to activate NF-κB in human microglial cells.

ABSTRACT:

Background

Chandipura virus (CHPV) is a negative single-stranded RNA virus of the Rhabdoviridae family. CHPV infection has been reported in Central and Western India. CHPV causes acute encephalitis with a case fatality rate of 70 % and mostly affects children below 15 years of age. CHPV infection in brain leads to neuronal apoptosis and activation of the microglial cells. The microRNAs (miRNAs) are small endogenous non-coding RNA that regulate the gene expression. Viral infections perturb the expression pattern of cellular miRNAs, which may in turn affect the expression pattern of downstream genes. This study aims to investigate hsa-miR-21-5p mediated regulation of PTEN, AKT, NF-ĸBp65, IL-6, TNF-α, and IL-1β, in human microglial cells during CHPV infection.

Methods

To unders

SUBMITTER: Pandey N 

PROVIDER: S-EPMC8265105 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature