The expression of miR-513c and miR-3163 was downregulated in tumor tissues compared with normal adjacent tissue of patients with breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is the most invasive cancer with different subtypes that its metabolism is unique compared with normal cells. Glutamine is considered critical nutrition that many cancer cells, particularly BC cells, are dependent on it for growth and proliferation. Therefore, targeting glutamine metabolism, especially enzymes that are related to this pathway, can be beneficial to design anti-cancer agents. Recent evidence has shown that microRNAs (miRNAs), with a short length and single-strand properties, play a prominent role in regulating the genes related to glutamine metabolism, which may control the development of cancer.

Methods

In silico analysis confirmed that miR-513c and miR-3163 might be involved in glutamine metabolism. The expression level of these

SUBMITTER: Delgir S 

PROVIDER: S-EPMC8265124 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature