Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review.

ABSTRACT: Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of adverse drug reactions (ADRs) due to drug-drug interactions. The risk is further increased in patients with chronic diseases/comorbidities who are more susceptible because of their genetic setup or external factors. In that light, we present a case of a 46-year-old woman who had been experiencing acute renal and hepatic injury and myalgia over two years of concomitant treatment with diclofenac, atorvastatin, simvastatin/fenofibrate, and several other drugs, including pantoprazole and furosemide. Our pharmacogenomic findings supported the suspi

SUBMITTER: Bozina N 

PROVIDER: S-EPMC8265195 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature