Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation.

ABSTRACT: At homeostasis the vast majority of neutrophils in the circulation expresses CD16 and CD62L within a narrow expression range, but this quickly changes in disease. Little is known regarding the changes in kinetics of neutrophils phenotypes in inflammatory conditions. During acute inflammation more heterogeneity was found, characterized by an increase in CD16^dim banded neutrophils. These cells were probably released from the bone marrow (left shift). Acute inflammation induced by human experimental endotoxemia (LPS model) was additionally accompanied by an immediate increase in a CD62L^low neutrophil population, which was not as explicit after injury/trauma induced acute inflammation. The situation in sub-acute inflammation was more complex. CD62L^low neutrophi

SUBMITTER: Bongers SH 

PROVIDER: S-EPMC8265311 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature