Relationship of HER2 Alteration and Microsatellite Instability Status in Colorectal Adenocarcinoma.

ABSTRACT:

Background

The impact of HER2 somatic mutations in colorectal carcinoma (CRC) has not been well studied and its relationship with microsatellite instability-high (MSI-H) is yet to be fully elucidated.

Materials and methods

From February 2017 to February 2020, the data of patients with CRC who underwent next-generation sequencing and had detailed record of clinicopathological information were investigated. HER2 alteration and its relationship with MSI-H were analyzed.

Results

Among 731 patients who underwent sequencing, 55 patients (7.5%) had HER2 alteration, including 29 (4.0%) with HER2 somatic mutations, 24 (3.3%) with HER2 gene amplification, and 2 patients (0.2%) with both HER2 mutations and amplification. R678Q was the most common mutated kinase domain, and no HE

SUBMITTER: Qiu MZ 

PROVIDER: S-EPMC8265359 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature