Defective Neuronal Positioning Correlates With Aberrant Motor Circuit Function in Zebrafish.

ABSTRACT: Precise positioning of neurons resulting from cell division and migration during development is critical for normal brain function. Disruption of neuronal migration can cause a myriad of neurological disorders. To investigate the functional consequences of defective neuronal positioning on circuit function, we studied a zebrafish frizzled3a (fzd3a) loss-of-function mutant off-limits (olt) where the facial branchiomotor (FBM) neurons fail to migrate out of their birthplace. A jaw movement assay, which measures the opening of the zebrafish jaw (gape), showed that the frequency of gape events, but not their amplitude, was decreased in olt mutants. Consistent with this, a larval feeding assay revealed decreased food intake in olt mutants, indicating th

SUBMITTER: Asante E 

PROVIDER: S-EPMC8265374 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature