Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization.

ABSTRACT: BIM is the master BH3-only BCL-2 family regulator of lymphocyte survival. To understand how long-term loss of BIM affects apoptotic resistance in T cells we studied animals with T cell-specific deletion of Bim. Unlike CD19^CREBim^fl/fl animals, LCK^CREBim^fl/fl mice have pronounced early lymphocytosis followed by normalization of lymphocyte counts over time. This normalization occurred in mature T cells, as thymocyte development and apoptotic sensitivity remained abnormal in LCK^CREBim^fl/fl mice. T cells from aged mice experienced normalization of their absolute cell numbers and responses against various apoptotic stimuli. mRNA expression levels of BCL-2 family proteins in CD4⁺ and CD8⁺ T cells from young an

SUBMITTER: Ludwig LM 

PROVIDER: S-EPMC8265391 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature