Emergence of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Coharboring a bla_NDM-1-Carrying Virulent Plasmid and a bla_KPC-2-Carrying Plasmid in an Egyptian Hospital.

ABSTRACT: The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Egyptian hospitals has been reported. However, the genetic basis and analysis of the plasmids associated with carbapenem-resistant hypervirulent K. pneumoniae (CR-HvKP) in Egypt have not been presented. Therefore, we attempted to decipher the plasmid sequences that are responsible for transferring the determinants of carbapenem resistance, particularly bla_NDM-1 and bla_KPC-2 Out of 34 K. pneumoniae isolates collected from two tertiary hospitals in Egypt, 31 were CRKP. Whole-genome sequencing revealed that our isolates were related to 13 different sequence types (STs). The most prevalent ST was ST101, followed by ST383 and ST11. Among the CRKP isolates, one

SUBMITTER: Ahmed MAEE 

PROVIDER: S-EPMC8265623 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature