Mitochondrial Contact Site and Cristae Organization System and F₁F_O-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae.

ABSTRACT: Mitochondrial cristae are polymorphic invaginations of the inner membrane that are the fabric of cellular respiration. Both the mitochondrial contact site and cristae organization system (MICOS) and the F₁F_O-ATP synthase are vital for sculpting cristae by opposing membrane-bending forces. While MICOS promotes negative curvature at crista junctions, dimeric F₁F_O-ATP synthase is crucial for positive curvature at crista rims. Crosstalk between these two complexes has been observed in baker's yeast, the model organism of the Opisthokonta supergroup. Here, we report that this property is conserved in Trypanosoma brucei, a member of the Discoba clade that separated from the Opisthokonta ∼2 billion years ago. Specifically, one of the paralogs of

SUBMITTER: Cadena LR 

PROVIDER: S-EPMC8265648 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature