Transcriptional Response of <i>Wolbachia</i> to Dengue Virus Infection in Cells of the Mosquito <i>Aedes aegypti</i>.

ABSTRACT: Aedes aegypti transmits one of the most significant mosquito-borne viruses, dengue virus (DENV). The absence of effective vaccines and clinical treatments and the emergence of insecticide resistance in A. aegypti necessitate novel vector control strategies. A new approach uses the endosymbiotic bacterium Wolbachia pipientis to reduce the spread of arboviruses. However, the Wolbachia-mediated antiviral mechanism is not well understood. To shed light on this mechanism, we investigated an unexplored aspect of Wolbachia-virus-mosquito interaction. We used RNA sequencing to examine the transcriptional response of Wolbachia to DENV infection in A. aegypti Aag2 cells transinfected with the wAlbB strain of Wolbachia. Our results sugges

SUBMITTER: Leitner M 

PROVIDER: S-EPMC8265661 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature