Ontology highlight
ABSTRACT:
SUBMITTER: Jeha S
PROVIDER: S-EPMC8265990 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Jeha Sima S Choi John J Roberts Kathryn G KG Pei Deqing D Coustan-Smith Elaine E Inaba Hiroto H Rubnitz Jeffrey E JE Ribeiro Raul C RC Gruber Tanja A TA Raimondi Susana C SC Karol Seth E SE Qu Chunxu C Brady Samuel W SW Gu Zhaohui Z Yang Jun J JJ Cheng Cheng C Downing James R JR Evans Williams E WE Relling Mary V MV Campana Dario D Mullighan Charles G CG Pui Ching-Hon CH
Blood cancer discovery 20210701 4
We evaluate clinical significance of recently identified subtypes of acute lymphoblastic leukemia (ALL) in 598 children treated with minimal residual disease (MRD)-directed therapy. Among the 16 B-ALL and 8 T-ALL subtypes identified by next generation sequencing, <i>ETV6-RUNX1</i>, high-hyperdiploid and <i>DUX4</i>-rearranged B-ALL had the best five-year event-free survival rates (95% to 98.4%); <i>TCF3-PBX1</i>, PAX5alt, T-cell, ETP, iAMP21, and hypodiploid ALL intermediate rates (80.0% to 88.2 ...[more]