A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is a heterogeneous disease characterized by high mortality and poor prognosis. Ferroptosis, a newly discovered iron-dependent type of cell death, has been found to play a crucial role in the development of cancers. However, little is known about the prognostic value of ferroptosis-related genes (FRGs) in LUAD.

Methods

In the present study, RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas (TCGA) database. Cox regression analysis was used to construct a multigene signature. Kaplan-Meier survival and receiver operating characteristic (ROC) curves were utilized to assess the prognostic prediction efficiency of the constructed survival model. LUAD patients from the GSE30219 dataset were used for validatio

SUBMITTER: Jin J 

PROVIDER: S-EPMC8266333 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature