The circadian clock is associated with prognosis and immune infiltration in stomach adenocarcinoma.

ABSTRACT:

Background

Stomach adenocarcinoma (STAD) is one of the most prevalent malignances and ranks fifth in incidence and third in cancer-related death among all malignances. The prognosis of STAD is poor. The circadian clock is regulated by interlocked transcriptional-translational feedback loops that orchestrate circadian rhythms in some biological processes, including the immune response and metabolism. However, the association between core circadian clock genes and STAD patient prognosis is unclear.

Materials and methods

In our study, bioinformatics methods were performed to explore the expression and prognostic value of core circadian clock genes in STAD and their association with immune infiltration.

Results

The mRNA levels of CLOCK, CRY1 and NR1D1 were upregulated, wh

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8266362 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature