Potential Foldamers Based on an ortho-Terphenyl Amino Acid.

ABSTRACT: We describe the synthesis and characterization of a new class of oligomers built from a terphenyl-based amino acid. These oligomeric amides are of interest because the adoption of specific conformations could potentially be driven by the coordinated formation of inter-residue hydrogen bonds and aromatic interactions. Although high-resolution structural data have proven inaccessible, circular dichroism and nuclear magnetic resonance studies suggest that the new oligomers fold concomitantly with discrete self-association in chloroform.

SUBMITTER: Kleman AF 

PROVIDER: S-EPMC8266378 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature