A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories.

ABSTRACT: Adaptive reward-related decision making often requires accurate and detailed representation of potential available rewards. Environmental reward-predictive stimuli can facilitate these representations, allowing one to infer which specific rewards might be available and choose accordingly. This process relies on encoded relationships between the cues and the sensory-specific details of the rewards they predict. Here, we interrogated the function of the basolateral amygdala (BLA) and its interaction with the lateral orbitofrontal cortex (lOFC) in the ability to learn such stimulus-outcome associations and use these memories to guide decision making. Using optical recording and inhibition approaches, Pavlovian cue-reward conditioning, and the outcome-selective Pavlovian-to-instrumental transf

SUBMITTER: Sias AC 

PROVIDER: S-EPMC8266390 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature