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Tyrosinase Inhibitors from the Stems of Streblus Ilicifolius.

ABSTRACT: Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of Streblus ilicifolius (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus C possesses strong tyrosinase inhibitory activity with an IC₅₀ value of 0.01 μM. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. The analysis of the docked poses confirmed that 1 showed better binding affinity for oxy-tyrosinase than that of 2.

SUBMITTER: Nguyen NT

PROVIDER: S-EPMC8266447 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Tyrosinase Inhibitors from the Stems of Streblus Ilicifolius.

Nguyen Nhan T NT Dang Phu H PH Nguyen Hai X HX Do Truong N V TNV Le Tho H TH Le Tuyen Q H TQH Nguyen Mai T T MTT

Evidence-based complementary and alternative medicine : eCAM 20210701

Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of Streblus ilicifolius (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus C possesses strong tyrosinase inhibitory activity with an IC50 value of 0.01 μM. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interacti ...[more]

PMID: 34306141

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Strebluses E-H, four new stilbene-like derivatives from the stems of Streblus ilicifolius.

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