Personalized Estimates of Brain Structural Variability in Individuals With Early Psychosis.

ABSTRACT:

Background

Early psychosis in first-episode psychosis (FEP) and clinical high-risk (CHR) individuals has been associated with alterations in mean regional measures of brain morphology. Examination of variability in brain morphology could assist in quantifying the degree of brain structural heterogeneity in clinical relative to healthy control (HC) samples.

Methods

Structural magnetic resonance imaging data were obtained from CHR (n = 71), FEP (n = 72), and HC individuals (n = 55). Regional brain variability in cortical thickness (CT), surface area (SA), and subcortical volume (SV) was assessed with the coefficient of variation (CV). Furthermore, the person-based similarity index (PBSI) was employed to quantify the similarity of CT, SA, and SV profile of each individual to ot

SUBMITTER: Antoniades M 

PROVIDER: S-EPMC8266574 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature