Biomarker Profiles in Psychosis Risk Groups Within Unaffected Relatives Based on Familiality and Age.

ABSTRACT: Investigating biomarkers in unaffected relatives (UR) of individuals with psychotic disorders has already proven productive in research on psychosis neurobiology. However, there is considerable heterogeneity among UR based on features linked to psychosis vulnerability. Here, using the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) dataset, we examined cognitive and neurophysiologic biomarkers in first-degree UR of psychosis probands, stratified by 2 widely used risk factors: familiality status of the respective proband (the presence or absence of a first- or second-degree relative with a history of psychotic disorder) and age (within or older than the common age range for developing psychosis). We investigated biomarkers that best differentiate the above specific risk s

SUBMITTER: Turkozer HB 

PROVIDER: S-EPMC8266584 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature