Long-Term Real-World Effectiveness of Pharmacotherapies for Schizoaffective Disorder.

ABSTRACT:

Objective

To investigate the long-term real-world effectiveness of antipsychotics and other psychopharmacotherapies in the treatment of schizoaffective disorder (SCHAFF).

Method

Two nationwide cohorts of SCHAFF patients were identified from Finnish and Swedish registers. Within-individual design was used with stratified Cox regression. The main exposure was use of antipsychotics. Adjunctive pharmacotherapies included mood stabilizers, antidepressants, and benzodiazepines and benzodiazepine-related drugs. The main outcome was hospitalization due to psychosis.

Results

The Finnish cohort included 7655 and the Swedish cohort 7525 patients. Median follow-up time was 11.2 years (IQR 5.6-11.5) in the Finnish and 7.6 years (IQR 3.8-10.3) in the Swedish cohort. Clozapine and l

SUBMITTER: Lintunen J 

PROVIDER: S-EPMC8266596 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature