Assessment and pathophysiology of microvascular disease: recent progress and clinical implications.

ABSTRACT: The development of novel, non-invasive techniques and standardization of protocols to assess microvascular dysfunction have elucidated the key role of microvascular changes in the evolution of cardiovascular (CV) damage, and their capacity to predict an increased risk of adverse events. These technical advances parallel with the development of novel biological assays that enabled the ex vivo identification of pathways promoting microvascular dysfunction, providing novel potential treatment targets for preventing cerebral-CV disease. In this article, we provide an update of diagnostic testing strategies to detect and characterize microvascular dysfunction and suggestions on how to standardize and maximize the information obtained from each microvascular assay. We examine emerging data highl

SUBMITTER: Masi S 

PROVIDER: S-EPMC8266605 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature