Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population.

ABSTRACT: Genetic liability for schizophrenia is associated with psychopathology in early life. It is not clear if these associations are time dependent during childhood, nor if they are specific across different forms of psychopathology. Using genotype and questionnaire data on children (N = 15 105) from the Norwegian Mother, Father and Child Cohort Study, we used schizophrenia polygenic risk scores to test developmental stability in associations with measures of emotional and behavioral problems between 18 months and 5 years, and domain specificity in associations with symptoms of depression, anxiety, conduct problems, oppositionality, inattention, and hyperactivity at 8 years. We then sought to identify symptom profiles-across development and domains-associated with schizophrenia polygenic liabil

SUBMITTER: Hannigan LJ 

PROVIDER: S-EPMC8266611 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature