White Matter Neurometabolic Signatures Support the Deficit and Nondeficit Distinction in Antipsychotic-Naive First-Episode Psychosis Patients.

ABSTRACT: The deficit syndrome is thought to be a more homogenous clinical subgroup within the syndrome of schizophrenia that is characterized by enduring negative symptoms. It is hypothesized that distinct pathophysiological processes underlie the subtypes, where the deficit syndrome reflects an early onset nonprogressive developmental process, and the nondeficit form of the illness is characterized by attenuated neuroplasticity secondary to elevated glutamate levels. We used single-voxel magnetic resonance spectroscopy (PRESS; TE: 30 ms) to measure left frontal white matter neurometabolite levels in 61 antipsychotic-naïve first-episode psychosis patients (39 who did not display deficit features, 22 who did display deficit features, assessed with the Schedule for the Deficit Syndrome) and 59 health

SUBMITTER: Bryant JE 

PROVIDER: S-EPMC8266628 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature