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Courier service for phosphatidylinositol: PITPs deliver on demand.

ABSTRACT: Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol lipids and each of them play specific roles in numerous processes including receptor-mediated signalling, actin cytoskeleton dynamics and membrane trafficking. PI synthesis is localised to the endoplasmic reticulum (ER) whilst its phosphorylated derivatives are found in other organelles where the lipid kinases also reside. Phosphorylation of PI to phosphatidylinositol (4,5) bisphosphate (PI(4,5)P₂) at the plasma membrane and to phosphatidylinositol 4-phosphate (PI4P) at the Golgi are key events in lipid signalling and Golgi function respectively. Here we review a family of proteins, phosphatidylinositol transfer proteins (PITPs), that can mobilise PI from the ER to provide the substrate to the resident kinases for phosphorylation. Recent studies identify specific and overlapping functions for the three soluble PITPs (PITPα, PITPβ and PITPNC1) in phospholipase C signalling, neuronal function, membrane trafficking, viral replication and in cancer metastases.

SUBMITTER: Ashlin TG

PROVIDER: S-EPMC8266687 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Courier service for phosphatidylinositol: PITPs deliver on demand.

Ashlin Tim G TG Blunsom Nicholas J NJ Cockcroft Shamshad S

Biochimica et biophysica acta. Molecular and cell biology of lipids 20210607 9

Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol lipids and each of them play specific roles in numerous processes including receptor-mediated signalling, actin cytoskeleton dynamics and membrane trafficking. PI synthesis is localised to the endoplasmic reticulum (ER) whilst its phosphorylated derivatives are found in other organelles where the lipid kinases also reside. Phosphorylation of PI to phosphatidylinositol (4,5) bisphosphate (PI(4,5)P<sub>2</s ...[more]

PMID: 34111527

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Courier service for phosphatidylinositol: PITPs deliver on demand.

Publications

Courier service for phosphatidylinositol: PITPs deliver on demand.

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