Production and scavenging of reactive oxygen species both affect reproductive success in male and female Drosophila melanogaster.

ABSTRACT: Sperm aging is accelerated by the buildup of reactive oxygen species (ROS), which cause oxidative damage to various cellular components. Aging can be slowed by limiting the production of mitochondrial ROS and by increasing the production of antioxidants, both of which can be generated in the sperm cell itself or in the surrounding somatic tissues of the male and female reproductive tracts. However, few studies have compared the separate contributions of ROS production and ROS scavenging to sperm aging, or to cellular aging in general. We measured reproductive fitness in two lines of Drosophila melanogaster genetically engineered to (1) produce fewer ROS via expression of alternative oxidase (AOX), an alternative respiratory pathway; or (2) scavenge fewer ROS due to a loss-of-function mutat

SUBMITTER: Turnell BR 

PROVIDER: S-EPMC8266701 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature