Dataset Information

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.

ABSTRACT: The preoptic area (POA) is a key brain region for regulation of body temperature (Tb), dictating thermogenic, cardiovascular, and behavioral responses that control Tb. Previously characterized POA neuronal populations all reduced Tb when activated. Using mice, we now identify POA neurons expressing bombesin-like receptor 3 (POA^BRS3) as a population whose activation increased Tb; inversely, acute inhibition of these neurons reduced Tb. POA^BRS3 neurons that project to either the paraventricular nucleus of the hypothalamus or the dorsomedial hypothalamus increased Tb, heart rate, and blood pressure via the sympathetic nervous system. Long-term inactivation of POA^BRS3 neurons caused increased Tb variability, overshooting both increases and decreases in Tb set point, with RNA expression profiles suggesting multiple types of POA^BRS3 neurons. Thus, POA^BRS3 neuronal populations regulate Tb and heart rate, contribute to cold defense, and fine-tune feedback control of Tb. These findings advance understanding of homeothermy, a defining feature of mammalian biology.

SUBMITTER: Pinol RA

PROVIDER: S-EPMC8266747 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.

Piñol Ramón A RA Mogul Allison S AS Hadley Colleen K CK Saha Atreyi A Li Chia C Škop Vojtěch V Province Haley S HS Xiao Cuiying C Gavrilova Oksana O Krashes Michael J MJ Reitman Marc L ML

Cell metabolism 20210525 7

The preoptic area (POA) is a key brain region for regulation of body temperature (Tb), dictating thermogenic, cardiovascular, and behavioral responses that control Tb. Previously characterized POA neuronal populations all reduced Tb when activated. Using mice, we now identify POA neurons expressing bombesin-like receptor 3 (POA<sup>BRS3</sup>) as a population whose activation increased Tb; inversely, acute inhibition of these neurons reduced Tb. POA<sup>BRS3</sup> neurons that project to either ...[more]

PMID: 34038711

Similar Datasets

Project description:BackgroundDespite centuries of research, debate remains on the scaling of metabolic rate to mass especially for intraspecific cases. The high variation of body mass within brown bears presents a unique opportunity to study the intraspecific effects of body mass on physiological variables. The amplitude of metabolic rate reduction in hibernators is dependent on body mass of the species. Small hibernators have high metabolic rates when euthermic but experience a drastic decrease in body temperature during torpor, which is necessary to reach a very low metabolic rate. Conversely, large hibernators, such as the brown bear (Ursus arctos), show a moderate decrease in temperature during hibernation, thought to be related to the bear's large size. We studied body mass, abdominal body temperature, heart rate, and accelerometer-derived activity from 63 free-ranging brown bears (1-15 years old, 15-233 kg). We tested for relationships between body mass and body temperature, heart rate, and hibernation duration.ResultsThe smallest individuals maintained lower body temperatures during hibernation, hibernated longer, and ended hibernation later than large bears. Unlike body temperature, winter heart rates were not associated with body mass. In summer, the opposite pattern was found, with smaller individuals having higher body temperature and daytime heart rates. Body mass was associated with body temperature in the winter hypometabolic state, even in a large hibernating mammal. Smaller bears, which are known to have higher thermal conductance, reached lower body temperatures during hibernation. During summer, smaller bears had higher body temperatures and daytime heart rates, a phenomenon not previously documented within a single mammalian species.ConclusionWe conclude that the smallest bears hibernated more deeply and longer than large bears, likely from a combined effect of basic thermodynamics, the higher need for energy savings, and a lower cost of warming up a smaller body.

Dataset Information

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.

Publications

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets