Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.

ABSTRACT: The preoptic area (POA) is a key brain region for regulation of body temperature (Tb), dictating thermogenic, cardiovascular, and behavioral responses that control Tb. Previously characterized POA neuronal populations all reduced Tb when activated. Using mice, we now identify POA neurons expressing bombesin-like receptor 3 (POA^BRS3) as a population whose activation increased Tb; inversely, acute inhibition of these neurons reduced Tb. POA^BRS3 neurons that project to either the paraventricular nucleus of the hypothalamus or the dorsomedial hypothalamus increased Tb, heart rate, and blood pressure via the sympathetic nervous system. Long-term inactivation of POA^BRS3 neurons caused increased Tb variability, overshooting both increases and decreases in Tb set p

SUBMITTER: Pinol RA 

PROVIDER: S-EPMC8266747 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature