Exposure to anesthesia is not associated with development of α-synucleinopathies: A nested case-control study.

ABSTRACT:

Introduction

Preclinical studies suggest that inhalational anesthetics may induce neuropathology changes in the nigrostriatal system, leading to development of α-synucleinopathies. We explored the role of general anesthesia in the development of Parkinson disease (PD) and other α-synucleinopathies.

Methods

All α-synucleinopathy cases in Olmsted County, Minnesota, from January 1991, to December 2010, were identified from diagnostic codes, and then reviewed for type and index date of diagnosis. Cases were matched by sex and age (±1 year) to a referent control, a resident living in Olmsted County, and free of α-synucleinopathies before the index date (year of onset of the α-synucleinopathy). Medical records of both cases and controls were reviewed for lifetime exposure to anest

SUBMITTER: Laporta ML 

PROVIDER: S-EPMC8266757 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature