An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function.

ABSTRACT: The release of neuropeptides from dense core vesicles (DCVs) modulates neuronal activity and plays a critical role in cognitive function and emotion. The granin family is considered a master regulator of DCV biogenesis and the release of DCV cargo molecules. The expression of the VGF protein (nonacronymic), a secreted neuropeptide precursor that also belongs to the extended granin family, has been previously shown to be induced in the brain by hippocampus-dependent learning, and its downregulation is mechanistically linked to neurodegenerative diseases such as Alzheimer's disease and other mood disorders. Currently, whether changes in translational efficiency of Vgf and other granin mRNAs may be associated and regulated with learning associated neural activity remains largely unknown. Here

SUBMITTER: Lin WJ 

PROVIDER: S-EPMC8266826 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature