DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy.

ABSTRACT: Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers. However, the adverse effects including normal tissues injury are also accompanied by the radiotherapy and chemotherapy. Targeted cancer therapy has the potential to suppress cancer cells' DNA damage response through tailoring therapy to cancer patients lacking specific DNA damage response functions. Obviously, understanding the broader role of DNA damage repair in cancers has became a basic and attractive strategy for targeted cancer therapy, in particular, raising novel hypothesis or theory in this field on the basis of previous scientists' findings would be important for

SUBMITTER: Huang R 

PROVIDER: S-EPMC8266832 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature