Vitamin D supplementation for children with cancer: A systematic review and consensus recommendations.

ABSTRACT:

Background

Prevalent vitamin D deficiency (VDD) and low bone mineral density (BMD) have led to vitamin D supplementation for children with cancer, regardless vitamin D status. However, it remains unsettled whether this enhances bone strength. We sought to address this issue by carrying out a systematic review of the literature.

Methods

We conducted a literature search using PubMed, Embase, and Cochrane databases. Studies including children up to 5 years after cancer therapy were assessed for the association between 25-hydroxyvitamin D (25OHD) levels and BMD Z-scores or fractures, and the effect of vitamin D supplementation on BMD or fractures. Evidence quality was assessed using the GRADE methodology.

Results

Nineteen studies (16 observational and 3 interventional, ma

SUBMITTER: van Atteveld JE 

PROVIDER: S-EPMC8267124 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature