A five-gene signature is a prognostic biomarker in pan-cancer and related with immunologically associated extracellular matrix.

ABSTRACT: The tumor microenvironment (TME) is related to extracellular matrix (ECM) dynamics and has a broad fundamental and mechanistic role in tumorigenesis and cancer progression. We hypothesized that ECM regulators might play an essential role in pan-cancer attribution by causing a generic effect through its regulation of the dynamics of ECM alteration. By analyzing data from TCGA using GSEA and univariate Cox regression analysis, we found that ECM regulator genes were significantly enriched and contributed to mortality in various cancer types. Notably, UMAP analysis revealed that ECM regulator genes dominated the differences between tumor and adjacent normal tissues based on 59 or 31 pan-survival-related ECM gene sets. Subsequently, a five-gene signature consisting of the predominant ECM regula

SUBMITTER: Yu C 

PROVIDER: S-EPMC8267129 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature