A randomized controlled trial of structured palliative care versus standard supportive care for patients enrolled in phase 1 clinical trials.

ABSTRACT:

Purpose

Patients enrolled in Phase 1 clinical trials have typically exhausted standard therapies and often are choosing between a clinical trial and hospice care. Significant symptom burden can result in early trial discontinuation and confound trial outcomes. This study aimed to examine differences in study duration, symptom burden, adverse events (AE), and quality of life (QOL) between those receiving structured palliative care versus usual supportive care.

Patients and methods

Sixty-eight patients enrolled in phase 1 clinical trials and 39 of their CGs were randomly assigned to receive structured palliative care or usual supportive care. Patient QOL was measured monthly using the Functional Assessment of Cancer Therapy and Memorial Symptom Assessment Scale. The Quality of

SUBMITTER: Treasure M 

PROVIDER: S-EPMC8267138 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature