Signature based on metabolic-related gene pairs can predict overall survival of osteosarcoma patients.

ABSTRACT:

Background

Osteosarcoma is a tumour of malignant origin in children and adolescents. Recent progression indicates that it is necessary to develop new therapies to improve the patient's prognosis rather than strengthen anti-tumour chemotherapy. Researchers recently realised that cancer is a kind of disease with a metabolic disorder, and metabolic reprogramming is becoming a new cancer hallmark. Hence, our study's primary purpose is to explore the value of genes related to osteosarcoma metabolism.

Methods

From public databases, three osteosarcoma datasets with adequate clinical information were obtained. Besides, the IMvigor dataset through the 'IMvigor' package as a supplement was downloaded, the metabolic-related genes were identified, and these genes were used to construct

SUBMITTER: Li LQ 

PROVIDER: S-EPMC8267140 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature