A modifiable risk factors atlas of lung cancer: A Mendelian randomization study.

ABSTRACT:

Background

There has been no study systematically assessing the causal effects of putative modifiable risk factors on lung cancer. In this study, we aimed to construct a modifiable risk factors atlas of lung cancer by using the two-sample Mendelian randomization framework.

Methods

We included 46 modifiable risk factors identified in previous studies. Traits with p-value smaller than 0.05 were considered as suggestive risk factors. While the Bonferroni corrected p-value for significant risk factors was set to be 8.33 × 10^-4 .

Results

In this two-sample Mendelian randomization analysis, we found that higher socioeconomic status was significantly correlated with lower risk of lung cancer, including years of schooling, college or university degree, and househol

SUBMITTER: Shen J 

PROVIDER: S-EPMC8267159 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature