Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis.

ABSTRACT:

Purpose

This study investigated the role of limitrin in the pathogenesis of demyelinating optic neuritis using an experimental autoimmune optic neuritis (EAON) model.

Methods

EAON was induced in mice via subcutaneous injection with myelin oligodendrocyte glycoprotein peptide. Limitrin protein and mRNA expression were examined in the optic nerve before and after EAON induction. Proinflammatory cytokine expression profiles and degree of glial activation were compared between wild-type (WT) and limitrin knockout mice by real-time PCR and histologic analysis, respectively, after EAON induction. Plasma limitrin levels in patients with optic neuritis and healthy controls were measured by ELISA.

Results

Limitrin expression, observed in astrocytes in the optic nerve of WT mic

SUBMITTER: Chun BY 

PROVIDER: S-EPMC8267184 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature