The central nervous system can directly regulate breast cancer progression and blockage by quercetin.

ABSTRACT:

Background

Neuroinflammation involving the central nervous system (CNS), such as depression, is associated with a significantly increased risk of cancer and cancer-specific mortality due to breast cancer. It is of great significance to learn about the regulatory process of CNS in breast cancer progression.

Methods

We established a depressive MMTV-PyVT mouse model. The expression levels of neurotransmitters in the serum of depression animal models were assessed by enzyme-linked immunosorbent assay (ELISA). Changes of the microglia cells in the mice's brains were evaluated by immunofluorescence and reverse transcription-polymerase chain reaction (RT-PCR). Breast cancer progression was assessed by immunohistochemistry (IHC) analysis. To further investigate the mechanism by whic

SUBMITTER: Luo T 

PROVIDER: S-EPMC8267261 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature