Protective effects of notoginsenoside R1 on acute lung injury in rats with sepsis.

ABSTRACT:

Background

To clarify the mechanism of notoginsenoside R1 in the treatment of septic acute lung injury (ALI) based on network pharmacological analysis, and to verify it in the model of septic ALI in rats.

Methods

Based on database searching, the related targets of notoginsenoside R1 and ALI were identified, and the component-disease-target network was constructed. The core targets were screened by protein-protein interaction (PPI), and the functional enrichment of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) was analyzed. The rat model of septic ALI was further established to investigate the pharmacological effects of notoginsenoside R1.

Results

Notoginsenoside R1 possibly affected ALI through 150 targets, of which 36 were core targets. GO sem

SUBMITTER: Cao B 

PROVIDER: S-EPMC8267269 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature