A novel peptide promotes human trophoblast proliferation and migration through PI3K/Akt/mTOR signaling pathway.

ABSTRACT:

Background

Preeclampsia (PE) is a complex pregnancy-related disease that endangers the safety of maternal and fetal. The purpose of this study is to reveal the pathogenesis of preeclampsia and discover new predictors from the perspective of peptidomics. The umbilical cord blood of PE and control group was analyzed by peptidomics. A peptide named Regulation of Proliferation Process in Preeclampsia (ROPPIP) was screened out to explore its role in the proliferation, migration and apoptosis of trophoblast cells in preeclampsia.

Methods

We compared and analyzed the umbilical cord blood of patients with PE and normal pregnant women using liquid chromatography-tandem mass spectrometry (LC-MS). hTR-8/Svneo cells cultured in vitro were divided into ROPPIP group and a disordere

SUBMITTER: Ling L 

PROVIDER: S-EPMC8267276 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature