The prognostic value of USP14 and PSMD14 expression in non-small cell lung cancer.

ABSTRACT:

Background

Ubiquitin specific peptidase 14 (USP14) and proteasome 26S subunit, non-ATPase 14 (PSMD14) are two deubiquitinases that are closely related to the human 19S proteasome. These are highly expressed in various types of cancers and are associated with prognosis. However, the expression, clinicopathological features, and prognostic relevance of these two deubiquitinases remain unclear in patients with non-small cell lung cancer (NSCLC). Moreover, the correlation between the expression of these two deubiquitinases in NSCLC has not been reported.

Methods

In this study, the expression of USP14 and PSMD14 in NSCLC tissues and adjacent non-tumor tissues were examined by immunohistochemical staining. The association of these two deubiquitinases with the clinicopathological f

SUBMITTER: Lei J 

PROVIDER: S-EPMC8267284 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature