Identification of genes predicting unfavorable prognosis in hepatitis B virus-associated hepatocellular carcinoma.

ABSTRACT:

Background

To identify potential key genes predicting unfavorable prognosis in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).

Methods

Gene expression profiles of GSE121248, GSE62232, and GSE55092 from the GEO database were obtained and analyzed. Differentially expressed genes (DEGs) between HBV-associated HCC tissues and adjacent normal tissues were screened by the limma package and Venn diagram software. Functional assessment of DEGs was performed by Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Hub genes were selected by the protein-protein interaction (PPI) network and further validated by GSE14520 clinical data.

Results

A total of 26 up-regulated genes and 76 down-regulated genes were identified by analyzing three d

SUBMITTER: Sha M 

PROVIDER: S-EPMC8267317 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature