MCTS1 promotes invasion and metastasis of oral cancer by modifying the EMT process.

ABSTRACT:

Background

The oncogene, malignant T-cell-amplified sequence 1 (MCTS1), has been found to be highly expressed in a variety of cancer cell lines. It has been shown to be involved in cell cycle progression and to confer a growth advantage for lymphomas and breast cancer. Nevertheless, the role of MCTS1 in contributing to the development of oral cancer remains elusive.

Methods

We analyzed the gene expression profiles of MCTS1 in normal oral keratinocytes and cancerous cells. Cellular proliferation, invasion, and migration experiments were performed to detect the effect of MCTS1 on the biological evolution of oral cancer. The in vitro results were verified by the in vivo lymphatic metastasis test. The underlying mechanism of MCTS1 in promoting oral cancer invasion

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8267330 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature