Ontology highlight
ABSTRACT:
SUBMITTER: Bansal P
PROVIDER: S-EPMC8267460 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Bansal Prakhar P Ahern Darcy T DT Kondaveeti Yuvabharath Y Qiu Catherine W CW Pinter Stefan F SF
Cell reports 20210601 10
Female human pluripotent stem cells (hPSCs) routinely undergo inactive X (Xi) erosion. This progressive loss of key repressive features follows the loss of XIST expression, the long non-coding RNA driving X inactivation, and causes reactivation of silenced genes across the eroding X (Xe). To date, the sporadic and progressive nature of erosion has obscured its scale, dynamics, and key transition events. To address this problem, we perform an integrated analysis of DNA methylation (DNAme), chroma ...[more]