Glutathione S-Transferase Polymorphisms and Clinical Characteristics in Autism Spectrum Disorders.

ABSTRACT: Background: Autism spectrum disorders (ASD) are a heterogeneous group of developmental disorders, with different levels of symptoms, functioning, and comorbidities. Recent findings suggested that oxidative stress and genetic variability in glutathione S-transferases (GSTs) might increase the risk of ASD development. We aimed to determine whether GST polymorphisms influence the severity of symptoms as well as the cognitive and adaptive abilities in children with ASD. Methods: The sample included 113 ASD cases. All participants were genotyped for GSTA1, GSTM1, GSTT1, and GSTP1 polymorphisms. The clinical characteristics were determined with Autism Diagnostic Interview-Revised (ADI-R) in all of the participants. In non-verbal participants, we explored the adaptive functioning us

SUBMITTER: Mandic-Maravic V 

PROVIDER: S-EPMC8267579 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature