Characteristics of Registered Studies of Chimeric Antigen Receptor Therapies: A Systematic Review.

ABSTRACT:

Importance

Hundreds of chimeric antigen receptor (CAR) therapies are under investigation for hematologic malignant cancers and solid malignant tumors. As the field of modern CAR therapy enters its second decade, clinical trials that demonstrate the efficacy of CAR therapies using randomized clinical trials (RCTs) and/or investigate methods to optimize patient outcomes with commercially available CAR therapies are increasingly important.

Objective

To analyze the landscape of registered CAR-related trials with dual focuses on trial methods and intent.

Evidence review

This systematic review identified 1304 ongoing or upcoming CAR-related trials registered at ClinicalTrials.gov as of December 22, 2020, and excluded 513 trials that did not pertain to cell-based therapy. Bo

SUBMITTER: Banerjee R 

PROVIDER: S-EPMC8267610 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature