Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review.

ABSTRACT: The prognosis of patients with oral squamous carcinoma (OSCC) largely depends on the stage at diagnosis, the 5-year survival rate being approximately 30% for advanced tumors. Early diagnosis, including the detection of lesions at risk for malignant transformation, is crucial for limiting the need for extensive surgery and for improving disease-free survival. Saliva has gained popularity as a readily available source of biomarkers (including cytokines) useful for diagnosing specific oral and systemic conditions. Particularly, the close interaction between oral dysplastic/neoplastic cells and saliva makes such fluid an ideal candidate for the development of non-invasive and highly accurate diagnostic tests. The present review has been designed to answer the question: "Is there evidence to su

SUBMITTER: Ferrari E 

PROVIDER: S-EPMC8267678 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature